Open AccessThe amino acid sequence of the light chain of human high‐molecular‐mass kiniogen
Author(s) -
LOTTSPEICH Friedrich,
KELLERMANN Josef,
HENSCHEN Agnes,
FOERTSCH Berthold,
MüLLERESTERL Werner
Publication year - 1985
Publication title -
european journal of biochemistry
Language(s) - English
Resource type - Journals
eISSN - 1432-1033
pISSN - 0014-2956
DOI - 10.1111/j.1432-1033.1985.tb09199.x
Subject(s) - histidine , peptide sequence , amino acid , peptide , immunoglobulin light chain , biochemistry , cystine , chemistry , sequence (biology) , homology (biology) , complete sequence , molecular mass , stereochemistry , biology , gene , genetics , cysteine , antibody , enzyme , genome
The complete amino acid sequence of the light chain of human high‐molicular‐mass kiningen has been determined. The peptide chain contains 255. Nine carbohydrate attachment sites were found. All carbohydrate side chains are O ‐glycosidically linked. Alignment of the present sequence with the bovine kininogen light chain sequence shows a high degree of homology, except for an extension of 22 amino acids within the histidine‐rich part of the sequence. The histidine‐rich region may have arisen by gene multiplication during evolution.