Open AccessMutations affecting the enzymes involved in the utilization of 4‐aminobutyric acid as nitrogen source by the yeast Saccharomyces cerevisiae
Author(s) -
RAMOS Fernando,
GUEZZAR Mounir,
GRENSON Marcelle,
WIAME JeanMarie
Publication year - 1985
Publication title -
european journal of biochemistry
Language(s) - English
Resource type - Journals
eISSN - 1432-1033
pISSN - 0014-2956
DOI - 10.1111/j.1432-1033.1985.tb08939.x
Subject(s) - saccharomyces cerevisiae , enzyme , yeast , biochemistry , nad+ kinase , chemistry , aminobutyric acid , metabolic pathway , dehydrogenase , biology , receptor
We present genetic evidence for the enzymes 4‐aminobutyrate: 2‐oxoglutarate aminotransferase (EC 2.6.1.19) and succinate‐semialdehyde dehydrogenase [NAD(P) + ] (EC 1.2.1.16) constituting the functional pathway for the utilization of 4‐aminobutyric acid as a nitrogen source by Saccharomyces cerevisiae . We show that the pathway is induced by 4‐aminobutyric acid and that the presence of the pathway enzymes probably requires the integrity of a positive control element.