Open AccessA Synthetic Ionophore for Ca 2+ : Studies with Model and Biological Systems
Author(s) -
GOMPERTS Bastien D.,
BENNETT Jonathan P.,
ALLAN David
Publication year - 1981
Publication title -
european journal of biochemistry
Language(s) - English
Resource type - Journals
eISSN - 1432-1033
pISSN - 0014-2956
DOI - 10.1111/j.1432-1033.1981.tb06373.x
Subject(s) - ionophore , histamine , chemistry , biophysics , calcium , phospholipid , biochemistry , membrane , biology , endocrinology , organic chemistry
We show that the relatively simple β‐diketone, 1,1,1.2,2,3,3‐heptafluoro‐7,7‐dimethyloctane‐d,6‐dione, known as ‘fod’, will solvate Ca 2+ ions in an organic phase. In consequence it will transport Ca 2+ across phospholipid bilayers. It acts as predicted for a Ca 2+ ‐transporting ionophore in two biological systems: it will stimulate Ca 2+ ‐dependent K + efflux from human red blood cells, and Cat + ‐dependent histamine secretion from rat peritoneal mast cells.