Open AccessThe Amino‐Acid Sequence of the α Subunit in Bovine Brain S‐100a Protein
Author(s) -
ISOBE Toshiaki,
OKUYAMA Tsuneo
Publication year - 1981
Publication title -
european journal of biochemistry
Language(s) - English
Resource type - Journals
eISSN - 1432-1033
pISSN - 0014-2956
DOI - 10.1111/j.1432-1033.1981.tb05303.x
Subject(s) - protein subunit , peptide sequence , gamma aminobutyric acid receptor subunit alpha 1 , amino acid , sequence (biology) , specificity factor , homology (biology) , biochemistry , interleukin 10 receptor, alpha subunit , biology , molecular mass , sequence homology , chemistry , g alpha subunit , enzyme , gene , rna , rna dependent rna polymerase
The brain specific S‐100 protein is a mixture of two components S‐100a and S‐100b with a subunit composition αβ or β 2 respectively. The amino acid sequence of the β subunit has been previously determined. This paper presents the sequence of the α subunit in the S‐100a protein. The α subunit consists of 93 amino‐acid residues and has a relative molecular mass of 10400. The sequence shows extensive homology (58%) with that of the β‐subunit and shares an apparent calcium binding site in the C‐terminal half of the molecule, suggesting a close evolutionary relationship between these subunits.