Open AccessTrans‐membrane Translocation of Proteins
Author(s) -
HEIJNE Gunnar
Publication year - 1980
Publication title -
european journal of biochemistry
Language(s) - English
Resource type - Journals
eISSN - 1432-1033
pISSN - 0014-2956
DOI - 10.1111/j.1432-1033.1980.tb05966.x
Subject(s) - chromosomal translocation , ovalbumin , membrane protein , sequence (biology) , computational biology , secretory protein , chemistry , microbiology and biotechnology , biology , membrane , biophysics , biochemistry , secretion , gene , genetics , antigen
A detailed, computerized procedure for analysing the translocation process of any protein with known sequence from a physico‐chemical point of view is presented and used to gain a better understanding of the molecular ‘rules’ that govern the final outcome of the process. With the aid of this procedure a number of testable predictions of the orientations of particular membrane‐bound proteins can be made. It is also suggested that ovalbumin, the only known secreted protein lacking a cleavable prepiece, initiates translocation in a way that differs from other secreted proteins.