Open AccessTrans‐membrane Translocation of Proteins
Author(s) -
HEIJNE Gunnar,
BLOMBERG Clas
Publication year - 1979
Publication title -
european journal of biochemistry
Language(s) - English
Resource type - Journals
eISSN - 1432-1033
pISSN - 0014-2956
DOI - 10.1111/j.1432-1033.1979.tb13100.x
Subject(s) - transmembrane protein , membrane protein , membrane , chemistry , biophysics , membrane transport , integral membrane protein , membrane transport protein , peripheral membrane protein , transport protein , microbiology and biotechnology , biochemistry , biology , receptor
As a start towards a deeper understanding of the transmembrane transport of proteins, the transfer of a nascent chain through the lipophilic core of a membrane is discussed from a physicochemical point of view. Some simple considerations of the energetics of protein structure, together with experimental data on the transfer process, form the basis for a detailed and quantifiable model, accounting for the extrusion of secreted proteins as well as for the insertion of trans‐membrane proteins.