Open AccessChemical Modifications of tyrosyl Residue(s) and Action of Human‐Fibroblast Interferon
Author(s) -
BERTHOLD Wolfgang,
TAN Celine,
TAN Y. H.
Publication year - 1978
Publication title -
european journal of biochemistry
Language(s) - English
Resource type - Journals
eISSN - 1432-1033
pISSN - 0014-2956
DOI - 10.1111/j.1432-1033.1978.tb12385.x
Subject(s) - residue (chemistry) , interferon , tyrosine , chemistry , biochemistry , amino acid residue , amino acid , chemical modification , biology , virology , peptide sequence , gene
Partially purified and purified human fibroblastoid interferon were iodinated and nitrared under experimental conditions in which the most likely amino acyl residue modified was tyrosine(s). The modification resulted in a loss of human interferon activity suggesting that tyrosyl residue(s) is associated with the antiviral action of human interferon.