Open AccessDecreased Heparin Sensitivity of Cyclohexanedione‐Modified Thrombin
Author(s) -
MACHOVICH Raymund,
STAUB Mária,
PATTHY László
Publication year - 1978
Publication title -
european journal of biochemistry
Language(s) - English
Resource type - Journals
eISSN - 1432-1033
pISSN - 0014-2956
DOI - 10.1111/j.1432-1033.1978.tb12113.x
Subject(s) - thrombin , antithrombin , heparin , chemistry , arginine , antithrombins , discovery and development of direct thrombin inhibitors , enzyme , biochemistry , sensitivity (control systems) , medicine , platelet , amino acid , electronic engineering , engineering
Modification of 5–6 arginine residues of thrombin with 1,2‐cyclohexanedione has resulted in the selective abolition of the heparin sensitivity of the enzyme's reaction with antithrombin‐III, whereas the antithrombin‐III sensitivity of native and modified thrombin was indistinguishable. It is suggested that heparin accelerates the thrombin antithrombin‐III reaction by interacting with thrombin.