Open AccessForssman Glycolipid Variants of Dog Gastric Mucosa
Author(s) -
SLOMIANY Bronislaw L.,
SLOMIANY Amalia
Publication year - 1978
Publication title -
european journal of biochemistry
Language(s) - English
Resource type - Journals
eISSN - 1432-1033
pISSN - 0014-2956
DOI - 10.1111/j.1432-1033.1978.tb12073.x
Subject(s) - glycolipid , ceramide , fucose , chemistry , biochemistry , hydrolysis , enzyme , antigen , glycosphingolipid , gastric mucosa , stereochemistry , biology , galactose , immunology , stomach , apoptosis
A fucose‐containing ceramide octasaccharide exhibiting Forssman antigenic activity, and reacting in human H anti‐H and anti‐A systems, was isolated from water‐soluble glycolipids of dog gastric mucosa. Defucosylation of the glycolipid resulted in the loss of H‐activity, but had no effect on its Forssman nor blood‐group A antigenic activity. The branched structure of glycolipid was identified by partial acid hydrolysis, sequential degradation with specific glycosidases and comparison of the permethylation products of the native and enzyme‐degraded compound. The structure of this glycolipid is proposed to be: