Open AccessRole of Thyroid Gland on the Peroxidase and lodinating Enzymes of Submaxillary Gland
Author(s) -
CHANDRA Tarasankar,
DAS Rakhahari,
DATTA Asoke G.
Publication year - 1977
Publication title -
european journal of biochemistry
Language(s) - English
Resource type - Journals
eISSN - 1432-1033
pISSN - 0014-2956
DOI - 10.1111/j.1432-1033.1977.tb11248.x
Subject(s) - submaxillary gland , thyroid , peroxidase , submandibular gland , thyroid peroxidase , endocrinology , medicine , enzyme , chemistry , biochemistry
The peroxidase (EC 1.11.1.7) and iodinase (EC 1.11.1.8) activities of rat submaxillary gland were found to be increased after thyroidectomy. The enzyme activities were maximal on the seventh day after operation and then decreased slightly. However, the enzyme activities were still more than 100% even 28 days following operation. Administration of thyroxine (10 μg/100 g body weight) prevented the increase. Puromycin, cycloheximide, and actinomycin D, the inhibitors of protein synthesis, as well as thiouracil partially abolished the increase of activities. These results suggest that thyroxine acts as a regulator of the iodinase and peroxidase enzyme(s) of submaxillary gland.