Open AccessA Precursor of Glycogen Biosynthesis: α‐1,4‐Glucan‐Protein
Author(s) -
KRISMAN Clara R.,
BARENGO Renée
Publication year - 1975
Publication title -
european journal of biochemistry
Language(s) - English
Resource type - Journals
eISSN - 1432-1033
pISSN - 0014-2956
DOI - 10.1111/j.1432-1033.1975.tb03979.x
Subject(s) - glycogen branching enzyme , glycogen synthase , glycogen , biosynthesis , biochemistry , chemistry , enzyme , glucan , glycogen debranching enzyme , atp synthase
The mechanism of glycogen biosynthesis in the absence of added primers takes place at least in two different steps. The first step could be initiated by a new enzyme named glycogen intiator synthase that catalyzes the transfer of glucose from UDP‐glucose to an acceptor protein. This step takes place in vitro only in the presence of some salts at high concentration. The complex product from this reaction has been isolated and demonstrated to act as a precursor for the synthesis of glycogen which takes place in the second step and is catalyzed by the already known glycogen synthase.