Open AccessDetermination of the Primary Structure of a Mouse IgG2a Immunoglobulin
Author(s) -
SCHIFF Claudine,
FOUGEREAU Michel
Publication year - 1975
Publication title -
european journal of biochemistry
Language(s) - English
Resource type - Journals
eISSN - 1432-1033
pISSN - 0014-2956
DOI - 10.1111/j.1432-1033.1975.tb02479.x
Subject(s) - immunoglobulin light chain , residue (chemistry) , kappa , antibody , protein primary structure , monoclonal antibody , peptide sequence , sequence (biology) , chemistry , microbiology and biotechnology , polypeptide chain , biology , stereochemistry , biochemistry , amino acid , genetics , mathematics , gene , geometry
The amino acid sequence of the light chain of the mouse monoclonal MOPC 173 immunoglobulin molecule (IgG2a,x) is presented. This kappa chain contains 214 residues. Comparisons of this sequence with murine kappa chains already published by other workers bring a confirmation of the large size of the murine Vx chain pool. A complete identity was found with the constant region of the light chain of MOPC 21 from residue 97 to residue 214.