Open AccessThe Kinetics of Substrate‐Competitive Inhibition in Ternary‐Complex Mechanisms for Enzyme Reactions Involving Two Substrates
Author(s) -
PETTERSSON Gösta
Publication year - 1974
Publication title -
european journal of biochemistry
Language(s) - English
Resource type - Journals
eISSN - 1432-1033
pISSN - 0014-2956
DOI - 10.1111/j.1432-1033.1974.tb03590.x
Subject(s) - ternary complex , ternary operation , kinetics , substrate (aquarium) , product inhibition , chemistry , enzyme , non competitive inhibition , mechanism (biology) , product (mathematics) , enzyme kinetics , stereochemistry , mathematics , active site , biochemistry , computer science , biology , physics , ecology , quantum mechanics , programming language , geometry
Generalized relationships for interpretation of the kinetics of competitive inhibition in ternary‐complex mechanisms for enzyme reactions involving two substrates have been derived. These relationships can be applied to any special case of the random mechanism indicated by Scheme I, including rapid‐equilibrium and compulsory‐order cases, and are also valid for more extended ternary‐complex mechanisms (Scheme II) in which abortive enzyme‐product‐substrate complexes and ternary enzyme‐product‐inhibitor complexes are formed.