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Ionic and Non‐Ionic Mitochondrial Phosphate in Relation to Ca 2+ and Arsenate Accumulation
Author(s) -
Harris Eric J.,
Wimhurst Janet M.,
Landaeta Isis
Publication year - 1974
Publication title -
european journal of biochemistry
Language(s) - English
Resource type - Journals
eISSN - 1432-1033
pISSN - 0014-2956
DOI - 10.1111/j.1432-1033.1974.tb03582.x
Subject(s) - arsenate , phosphate , chemistry , mitochondrion , ionic bonding , stoichiometry , salt (chemistry) , inorganic chemistry , ion , arsenic , biochemistry , organic chemistry
The distributions of phosphate and of a dicarboxylate were compared in rat liver mitochondria. The phosphate can be divided into an ionised part, assuming a Donnan relation holds between it and the other anion, and a non‐ionised part which is found to be stoichiometrically related in the ratio 1:1.8 to the mitochondrial Ca content. When arsenate and phosphate distributions are compared, the distribution calculated for ionised phosphate corresponds to that measured for the arsenate. The ionised phosphate was deduced from the total by deduction of an amount calculated to be equivalent to the Ca content. Both sets of results support the concept of mitochondria normally carrying non‐ionised phosphate as the Ca salt. A competition between arsenate and ionised phosphate for accumulation is described.

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