Open AccessSequence of Amino Acids of the NH 2 ‐Terminal Region of a Mouse‐Clonal Immunoglobulin Heavy Chain
Author(s) -
Bourgois Alain,
Fougereua Michel,
Preval Claude
Publication year - 1972
Publication title -
european journal of biochemistry
Language(s) - English
Resource type - Journals
eISSN - 1432-1033
pISSN - 0014-2956
DOI - 10.1111/j.1432-1033.1972.tb19705.x
Subject(s) - cyanogen bromide , immunoglobulin heavy chain , heavy chain , antibody , peptide sequence , amino acid , sequence (biology) , immunoglobulin light chain , chemistry , plasmacytoma , chain (unit) , microbiology and biotechnology , biology , biochemistry , genetics , immunology , gene , multiple myeloma , physics , astronomy
The amino acid sequence of the cyanogen bromide fragments H 1 ‐H 3 from the γ chain of the plasmacytoma immunoglobulin MOPC 173 is reported. It represents the first 104 amino acid residues of this heavy chain, thus covering the major part of the V H region. This sequence allowed definition of a third subgroup of variability for the heavy chain pool, in common between mouse and human immunoglobulins.