Open AccessRegulation of a Catabolic Pathway
Author(s) -
Vandecasteele JeanPaul,
Hermann Monique
Publication year - 1972
Publication title -
european journal of biochemistry
Language(s) - English
Resource type - Journals
eISSN - 1432-1033
pISSN - 0014-2956
DOI - 10.1111/j.1432-1033.1972.tb02503.x
Subject(s) - lysine , oxygenase , biochemistry , chemistry , catabolism , pseudomonas putida , enzyme , inducer , amino acid , gene
1 The regulation of the pathway responsible for l ‐lysine degradation in Pseudomonas putida has been studied. It has been shown that l ‐lysine is the actual inducer of the two first enzymes of the pathway, lysine oxygenase and 5‐aminovaleramidase. 2 No important repression of lysine oxygenase by various carbon sources and by intermediates of the lysine degradation pathway has been found. 3 Activation of lysine oxygenase by its substrate, lysine, has been observed. A physiological function for this phenomenom is proposed. 4 Sodium and potassium ions are activators whereas magnesium ion, phosphate and phosphorylated compounds are inhibitors of lysine oxygenase. Citrate also is inhibitory.