Open AccessEffect of Inhibition of Cholesterol Synthesis on the Secretion of Bile Salts in the Rat
Author(s) -
ALAM Nargis A.,
GLOVER John
Publication year - 1972
Publication title -
european journal of biochemistry
Language(s) - English
Resource type - Journals
eISSN - 1432-1033
pISSN - 0014-2956
DOI - 10.1111/j.1432-1033.1972.tb01853.x
Subject(s) - enterohepatic circulation , medicine , chenodeoxycholic acid , cholic acid , endocrinology , bile acid , chemistry , cholesterol , secretion , biology
1 The concentrations of bile acids, cholesterol and phospholipids were determined in fistula bile of rats given oral doses of AY 9944 ( trans ‐1,4‐bis(2‐chlorobenzylaminomethyl)cyclohexane dihydrochloride] (5 mg/kg body wt) daily for 7 days and in that of controls. 2 Both the cholesterol and bile salt secretions in the fistula bile of the treated rats on a sterolfree diet was 15 to 20% below that of controls. 3 The biliary concentration of phospholipids, on the other hand, was only reduced 7–10% by the drug. 4 The proportion of chenodeoxycholic acid to cholic acid was higher in the dosed animals (1:3.5) compared to controls (1:6) indicating that the drug either directly or indirectly also inhibits the 12α‐hydroxylase step in bile acid synthesis. 5 A lower bile acid pool in the enterohepatic circulation of doses rats would partly explain the previously observed poorer intestinal absorption of retinol by rats given AY 9944.