Open AccessInteraction between Arginase and Ornithine Carbamoyltransferase in Saccharomyces cerevisiae
Author(s) -
Messenguy Francine,
Penninckx Michel,
Wiame JeanMarie
Publication year - 1971
Publication title -
european journal of biochemistry
Language(s) - English
Resource type - Journals
eISSN - 1432-1033
pISSN - 0014-2956
DOI - 10.1111/j.1432-1033.1971.tb01542.x
Subject(s) - ornithine carbamoyltransferase , arginase , ornithine , biochemistry , arginine , saccharomyces cerevisiae , urea cycle , biology , chemistry , amino acid , gene
The inhibition of ornithine carbamoyltransferase by arginase in Saccharomyces cerevisiae , which is under the control of arginine and ornithine, involves a regulatory site on the ornithine carbamoyltransferase distinct from its catalytic site. This regulatory site is responsible for the partial inhibition of ornithine carbamoyltransferase by excess of ornithine. The strong inhibition of ornithine carbamoyltransferase by arginase in the presence of arginine requires the integrity of the mechanism which leads to partial inhibition by excess of ornithine.