Open AccessThe Binding of Americium and Plutonium to Bone Glycoproteins
Author(s) -
Chipperfield Alan R.,
Taylor David M.
Publication year - 1970
Publication title -
european journal of biochemistry
Language(s) - English
Resource type - Journals
eISSN - 1432-1033
pISSN - 0014-2956
DOI - 10.1111/j.1432-1033.1970.tb01203.x
Subject(s) - americium , plutonium , chemistry , glycoprotein , radiochemistry , biochemistry , nuclear chemistry
By means of a gel filtration technique it is shown that plutonium and americium differ in their mode of binding to two glycoproteins isolated from bovine cortical bone. Plutonium binds more strongly than americium, plutonium binding is maximal at pH 6 and americium at pH 8, and sialic acid is involved in the binding of plutonium but not americium. The mechanisms by which these elements bind to glycoproteins in vitro are discussed.