Open AccessHemoglobin‐Lepore Baltimore , a Third Type of a δβ Crossover (δ 50 , β 86 )
Author(s) -
Ostertag W.,
Smith E. W.
Publication year - 1969
Publication title -
european journal of biochemistry
Language(s) - English
Resource type - Journals
eISSN - 1432-1033
pISSN - 0014-2956
DOI - 10.1111/j.1432-1033.1969.tb00700.x
Subject(s) - crossover , hemoglobin , genetics , selection (genetic algorithm) , type (biology) , biology , computer science , biochemistry , artificial intelligence , ecology
A new Lepore‐type hemoglobin in a person of Negro descent has been identified. In this person a minor hemoglobin (Hb‐Lepore Baltimore ) was detected. An abnormal δβ‐chain was isolated and fingerprinted. This hybrid‐type protein presumably arose as a consequence of unequal crossing over between the δ and β genes, as was concluded for Hb‐Lepore Boston and Hb‐Lepore Hollandia . In the new Lepore‐type hemoglobin described here the crossover could be placed between residues δ 50 and β 86 . This type of crossover should occur with the highest frequency if crossing over is equally frequent between any nucleotide and if selection favours none of the crossover types.