Open AccessMetabolism of Prostaglandins in Rat Liver Mitochondria
Author(s) -
Hamberg M.
Publication year - 1968
Publication title -
european journal of biochemistry
Language(s) - English
Resource type - Journals
eISSN - 1432-1033
pISSN - 0014-2956
DOI - 10.1111/j.1432-1033.1968.tb00430.x
Subject(s) - prostaglandin , prostaglandin f , chemistry , prostaglandins f , prostaglandin e , medicine , metabolism , prostaglandin e2 , oxidizing agent , endocrinology , enzyme , biochemistry , biology , organic chemistry
A series of prostaglandins has been incubated with the β‐oxidizing enzyme system of rat liver. All of the compounds tested were oxidized. Prostaglandin E 1 , prostaglandin B 1 , prostaglandin F 1α and prostaglandin F 1β were converted into the corresponding C 18 homologues. Prostaglandin A 1 , 11α,15‐dihydroxy‐9‐ketoprostanoic acid and 11α‐hydroxy‐9,15‐diketoprostanoic acid yielded mixtures of the C 16 and C 18 homologues. Nor‐prostaglandin F 1α and homo‐prostaglandin F 1α were both converted into trinor‐prostaglandin F 1α .