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Pathogen inactivation technology applied to a blood component collected from an asymptomatic carrier of Leishmania infantum : a case report
Author(s) -
JimenezMarco T.,
Fisa R.,
Riera C.,
GironaLlobera E.,
Sedeño M.,
Saura A.,
Iniesta L.,
Guillen C.,
Muncunill J.
Publication year - 2012
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.2012.01622.x
Subject(s) - leishmania infantum , asymptomatic , asymptomatic carrier , pathogen , leishmania , virology , polymerase chain reaction , immunology , leishmaniasis , medicine , biology , parasite hosting , visceral leishmaniasis , pathology , genetics , world wide web , computer science , gene
Asymptomatic Leishmania infections have been the main cause of transfusion transmission in endemic areas. Polymerase chain reaction has been used to detect L. infantum DNA in the peripheral blood of asymptomatic Leishmania carriers. In our region, the prevalence of asymptomatic L. infantum infection in donors is markedly high (5·9% of donors studied). We investigated the ability of pathogen inactivation technology, using amotosalen and UVA illumination, to eliminate L. infantum in a blood component collected from an asymptomatic L. infantum infected donor. This is the first report of the INTERCEPT system being used to eliminate a parasite from a component collected from a donor.