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Exchange transfusions and top‐up transfusions in neonates with Kell haemolytic disease compared to Rh D haemolytic disease
Author(s) -
Rath M. E. A.,
SmitsWintjens V. E. H. J.,
Lindenburg I. T. M.,
Brand A.,
van Kamp I. L.,
Oepkes D.,
Walther F. J.,
Lopriore E.
Publication year - 2011
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.2010.01408.x
Subject(s) - haemolytic disease , exchange transfusion , medicine , interquartile range , retrospective cohort study , blood transfusion , pediatrics , disease , isoantibodies , pregnancy , antibody , immunology , fetus , biology , genetics
Objective To evaluate neonatal outcome in Kell haemolytic disease compared to Rh D haemolytic disease. Study design Retrospective study of all (near)‐term neonates with Kell ( n = 34) and Rh D haemolytic disease ( n = 157) admitted to our centre between January 2000 and December 2008. We recorded the need for exchange transfusion and top‐up transfusions up to 3 months of age. Results Neonates in the Kell group required less days of phototherapy than neonates in the Rh D group [2·4 vs. 4·1 days, respectively ( P < 0·01)]. The percentage of neonates requiring an exchange transfusion was lower in the Kell group than in the Rh D group [6% (2/34) and 62% (98/157), respectively ( P < 0·01)]. The percentage of neonates in the Kell group and Rh D group requiring a top‐up transfusion was 62% (21/34) and 72% (113/157), respectively ( P = 0·20). The median number of top‐up transfusions per neonate in the Kell group and Rh D group was 1 [interquartile range (IQR) 0–2] and 2(IQR 0–2), respectively ( P = 0·07). Conclusion Neonates with Kell haemolytic disease require less phototherapy and less exchange transfusions compared to neonates with Rh D haemolytic disease, but an equal number of top‐up transfusions.