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Accumulation of soluble inflammatory mediators between blood donation and pre‐storage leucocyte depletion
Author(s) -
Chudziak D.,
Sireis W.,
Pfeiffer H.U.,
Henschler R.,
Seifried E.,
Bönig H.
Publication year - 2009
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.2008.01132.x
Subject(s) - cytokine , blood donor , immunology , whole blood , donation , chemistry , proinflammatory cytokine , medicine , inflammation , economics , economic growth
Background and Objectives Leucocyte‐derived cytokines accumulate in stored whole blood. Pre‐storage leucocyte depletion has reduced cytokine levels and, consequently, febrile non‐haemolytic transfusion reactions. As leucocyte filtration and component separation can be performed until 24 h after donation, we hypothesized that within this time, inflammatory cytokines might accumulate. Materials and Methods Serial plasma samples were collected 4, 10 and 20 h after donation and cytokine concentrations were measured. Results Interleukin‐8 increased > 20‐fold and soluble CD40 ligand > sixfold during the observation time, less pronounced changes for several other mediators were also observed. Conclusion Leucocyte depletion within 10 h of blood donation will reduce the concentrations of pyrogenic mediators.