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Patient‐specific transfusion‐related acute lung injury
Author(s) -
Muniz M.,
Sheldon S.,
Schuller R. M.,
Young N. S.,
Klein H. G.,
Leitman S. F.,
Stroncek D. F.
Publication year - 2008
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.2007.00982.x
Subject(s) - transfusion related acute lung injury , medicine , chills , platelet , antibody , platelet transfusion , immunology , lung , pulmonary edema
Transfusion‐related acute lung injury (TRALI) is one of the leading causes of transfusion‐associated mortality. The inadvertent transfusion of neutrophil antibodies can cause pulmonary transfusion reactions and TRALI. However, not all patients transfused with neutrophil antibodies experience transfusion reactions. A 22‐year‐old man with severe aplastic anaemia (SAA) experienced TRALI after a platelet transfusion. The donor was found to be alloimmunized to human neutrophil antigen (HNA)‐3a, an antigen expressed by neutrophils from approximately 90% of Caucasians. Eleven other platelet components from this donor were transfused prior to this event and two caused reactions: one chills and one TRALI. Both episodes of TRALI occurred in the same male patient with SAA. The fact that one patient experienced TRALI following both exposures to anti‐HNA‐3a from the same donor whereas nine other recipients did not adds evidence to the observation that patient factors make a significant contribution to neutrophil antibody‐mediated transfusion reactions.