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A novel B var allele (547 G>A) demonstrates differential expression depending on the co‐inherited ABO allele
Author(s) -
Cho D.,
Kim S. H.,
Ki C. S.,
Choi K. L.,
Cho Y. G.,
Song J. W.,
Shin J. H.,
Suh S. P.,
Yazer M. H.,
Ryang D. W.
Publication year - 2004
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.2004.00575.x
Subject(s) - allele , abo blood group system , genetics , genotype , biology , context (archaeology) , phenotype , microbiology and biotechnology , gene , paleontology
Background and Objectives Genetic analysis of group B donors in Korea was performed. Materials and Methods Exons 6 and 7 were sequenced in 12 phenotypically B 3 donors 6 B 3 , 6 A 1 B 3 . Results Consensus sequences all B 3 and 2/6 A 1 B 3 donors were present. Four A 1 B 3 donors demonstrated a novel B allele, B var , in the context of A101/ or A102 / B var genotypes. Family studies based on an A 1 B 3 donor with the B var allele and on another unrelated subject with identical genotype and phenotype revealed B var /O01 genotypes with full B‐antigen expression. Conclusions Bvarallele is subject to differential expression, depending on the co‐inherited ABO allele.