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Blood Cell Precursors in Context. Composition of the Bone Marrow Microenvironment that Supports B Lymphopoiesis
Author(s) -
Kincade P.W.,
Yamashita Y.,
Borghesi L.,
Medina K.,
Oritani K.
Publication year - 1998
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1998.tb05430.x
Subject(s) - lymphopoiesis , bone marrow , context (archaeology) , blood cell , immunology , chemistry , medicine , stem cell , haematopoiesis , microbiology and biotechnology , biology , paleontology
New molecular approaches are rapidly yielding information about the composition of bone marrow and culture studies suggest possible functions for many molecules in that organ. However, the marrow is extraordinarily complex with respect to interactions between cells and their behaviour may not be adequately modeled in culture. It is becoming apparent that post‐translational modifications and function of proteins can be highly influenced by the cellular and extracellular environment. Therefore, in vivo studies will continue to be important for understanding this remarkable organ.