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Coagulation Factor Activation in Stored Platelet Concentrates is Modulated by the Platelets
Author(s) -
GyöngyössyIssa Maria I. C.,
Black Timothy,
Devine Dana V.
Publication year - 1996
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1996.tb01297.x
Subject(s) - platelet , coagulation , partial thromboplastin time , chemistry , platelet activation , thromboplastin , prothrombin time , platelet factor 4 , tissue factor , immunology , medicine , andrology
To assess alterations in coagulation proteins in stored platelet concentrates, we used a series of platelet parameters and measures of coagulation activation to compare samples collected before unit donation, during the processing of platelet concentrates (PC) from CPDA‐1 blood, and in storage up to 5 days as well as stored platelet‐poor plasma (PPP). Storage‐dependent increases in activated partial thromboplastin time and prothrombin time were seen in both PC and PPP. However, FVII, FXI, FXII, kallikrein activity and prothrombin F1.2 levels remained unchanged in stored PC. Surprisingly, in stored PPP, significant alterations in FXII, FVII, kallikrein and prothrombin F1.2 levels were seen. Platelet morphology and surface marker studies demonstrated platelet activation during storage. These data suggest that the presence of platelets in the CLX storage container partially suppresses coagulation activation at significant cost to platelet viability.