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Significance of Anti‐LU8 in Pregnancy
Author(s) -
Watt J.,
Jones M.L.,
Rose P.,
Pepper R.
Publication year - 1995
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1995.tb02565.x
Subject(s) - antibody dependent cell mediated cytotoxicity , antibody , haemolytic disease , pregnancy , medicine , immunology , isoantibodies , antigen , coombs test , cytotoxicity , chemistry , biology , fetus , in vitro , monoclonal antibody , genetics , biochemistry
Anti‐LU8, an antibody defining a high‐frequency antigen in the Lutheran system, was identified in the serum of a gravida 4 para 0 pregnant woman who had never been transfused. The antibody consisted of both an IgM and an IgG1 component and was nonreactive in the antibody‐dependent cell‐mediated cytotoxicity (ADCC) assay. The red cells of the mother and 3 siblings of the patient typed as LU:8,14 and were incompatible with the patient's serum. The baby was born at term with a negative direct antiglobulin test and typed as LU:8,14. There was no clinical evidence of haemolytic disease of the newborn.