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Transmission of Hepatitis C Virus by Anti‐HCV‐Negative Blood Transfusion: Case Report
Author(s) -
Vrielink H.,
Poel C.L.,
Reesink H.W.,
Zaaijer H.L.,
Lelie P.N.
Publication year - 1995
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1995.tb02546.x
Subject(s) - medicine , window period , hepatitis c virus , blood donor , antibody , transmission (telecommunications) , blood transfusion , donation , immunology , virology , hepatitis c , virus , serology , economic growth , economics , electrical engineering , engineering
Acute posttransfusion hepatitis C was reported in a recipient of 3 units of red cells. The recipient became acutely icteric 6 weeks after transfusion, and HCV infection was diagnosed. Stored serum samples of the 3 implicated donations, which were negative with ELISA‐2, were retested by PCR and 3rd‐generation antibody tests. One implicated donation was PCR positive, but anti‐HCV negative. Both other donations were negative in all tests. The donor was recalled to the Blood Bank 13 weeks after the implicated donation and was found to be ELISA‐3 plus RIBA‐3 positive. Eight months after the implicated donation, the donor is still PCR and RIBA‐3 positive, whereas the recipient became PCR negative but remained anti‐HCV RIBA‐3 positive. The case shows that blood products from donors collected during the open window period of an HCV infection can transmit HCV to recipients.