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The Therapeutic Value of HPA‐1a‐Negative Platelet Transfusion in Post‐Transfusion Purpura Complicated by Life‐Threatening Haemorrhage
Author(s) -
Win Nay,
Peterkin M.A.,
Watson W.H.
Publication year - 1995
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1995.tb01685.x
Subject(s) - medicine , platelet , purpura (gastropod) , platelet transfusion , hysterectomy , blood transfusion , antibody , surgery , anesthesia , immunology , ecology , biology
Post‐transfusion purpura (PTP) was diagnosed in a female patient 1 week after transfusion for hysterectomy. Despite treatment with oral steroids and intravenous immunoglobulin, platelet counts remained low, and the patient developed profuse rectal bleeding. Random platelet transfusion is reported to be ineffective in PTP. We report a case in which the transfusion of HPA‐1a negative platelets provided good increment and clinical haemostasis before intravenous immunoglobulin could have had an effect.