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Tolerability and Kinetics of a Solvent‐Detergent‐Treated Intravenous Immunoglobulin Preparation in Hypogammaglobulinaemia Patients
Author(s) -
Ebeling Freja,
Baer Maija,
Hormila Pirkko,
Järventie Greta,
Koistinen Pirjo,
Kätkä Kalevi,
Oksanen Kalevi,
Perkkiö Mikko,
Ruutu Tapani,
Soppi Esa,
Veijola Lea,
Myllylä Gunnar
Publication year - 1995
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1995.tb01675.x
Subject(s) - tolerability , intravenous infusions , medicine , adverse effect , antibody , kinetics , gastroenterology , immunoglobulin g , pharmacology , immunology , physics , quantum mechanics
The tolerability and kinetics of a solvent‐detergent‐treated 6% intravenous immunoglobulin (IVIG) preparation were studied in 15 hypogammaglobulinaemia patients during 3–4 regular substitution infusions of 9–18 g, the mean dose being 359 mg/kg. The infusions were well tolerated, and the trough serum IgG levels achieved were comparable to two commercial IVIG preparations. The stepwise increase of the infusion rate up to 5 mg/kg/min and the use of this IVIG as a 12% solution were possible without serious adverse events in all the 6 studied hypogammaglobulinaemia patients. This greatly reduced the time needed for the infusions.