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Performance Evaluation of a Particle Agglutination Test for Antibody to Human Immunodeficiency Virus 1: Comparison with Enzyme Immunoassay
Author(s) -
Elavia A.J.,
Thomas A.,
Nandi J.,
Coyaji G.D.,
BhavalkarPotdar V.
Publication year - 1995
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1995.tb00343.x
Subject(s) - immunoassay , human immunodeficiency virus (hiv) , virology , antibody , agglutination (biology) , medicine , direct agglutination test , immunology , serology
A performance evaluation of a particle agglutination test (PAT), manufactured by Fujirebio Inc., Japan (Serodia‐HIV), for antibody to human immunodeficiency virus type 1 (anti‐HIV‐1) was carried out and compared with a currently available enzyme immunoassay (EIA), manufactured by Genetic Systems Corp., USA, (HIV‐1/HIV‐2 EIA). Testing 2,878 Indian donor and patient samples, both tests showed 100% sensitivity and comparable specificity (PAT: 99.8%; EIA: 99.7% among donor samples). We conclude that PAT is a specific and sensitive test for anti‐HIV‐1; it is simple to perform and does not require sophisticated equipment. Hence it is suitable for mass screening of blood donors in a developing country like India, especially in rural areas where presently no HIV‐testing facilities are available.