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Type 2 T‐Cell‐Independent Murine Immune Response to the Human AB0 Blood Group Antigens
Author(s) -
Néron Sonia,
Lemieu Réal
Publication year - 1994
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1994.tb05041.x
Subject(s) - immune system , antigen , immunology , blood group antigens , blood type (non human) , biology , medicine , virology , abo blood group system
The human AB0 blood group determinants are simple carbohydrate structures which are widely distributed in nature. Much work has been done on the structure of the A and B antigens but little is known on the regulation of anti‐A and anti‐B immune responses. To develop a model system, we have characterized the AB0 immunity of normal Balb/c mice and found a significant level of serum natural anti‐A but almost no anti‐B. This finding and the known IgM predominance among immune anti‐A produced in the Balb/c mouse indicate that the AB0 immunity of this mouse strain is comparable to the one of human blood group B individuals. Following immunization with human red blood cells, similar levels of anti‐A were produced in normal and athymic Balb/c mice showing that the anti‐A response is T cell independent. Furthermore, no anti‐A or anti‐B antibodies were produced in CBA/xid mice indicating a type 2 T‐cell‐independent immune response. These results may contribute to a better understanding of human AB0 responses and establish the mouse as a suitable model to study the immunobiology of AB0 antigens.