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Monoclonal IgM Cold Agglutinins with Anti‐Pr 1d Specificity in a Patient with Peripheral Neuropathy
Author(s) -
Herron B.,
Willison H.J.,
Veitch J.,
Roelcke D.,
Illis L.S.,
Boulton F.E.
Publication year - 1994
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1994.tb05039.x
Subject(s) - cold agglutinin , immunology , peripheral neuropathy , medicine , sialic acid , polyneuropathy , immunoglobulin m , paraproteinemias , cold agglutinin disease , gammopathy , glycophorin , antibody , antigen , monoclonal , monoclonal antibody , biology , biochemistry , pathology , immunoglobulin g , endocrinology , autoantibody , diabetes mellitus
A patient with a demyelinating sensory motor polyneuropathy secondary to IgM paraproteinaemia is reported. The paraprotein binds to the gangliosides GD1b, GT1b, GQ1b and GD3, all of which contain disialosyl groups with the sequence NeuAcα2–8NeuAcα2–3Gal. The paraprotein also acts as a cold agglutinin recognising the sialic‐acid‐dependent Pr 1d antigenic determinant of the red cell membrane glycophorins. In this and in similar cases that have been reported, the coexistence of anti‐Pr cold agglutinins and peripheral neuropathy suggest that they might be the causative agents of the disease.