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Production of a Murine Monoclonal Antibody to the Low‐Incidence Red Cell Antigen Wr a : Characterisation and Comparison with Human Anti‐Wr a
Author(s) -
Ring S.M.,
Green C. A.,
Swallow D. M.,
Tippett P.
Publication year - 1994
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1994.tb01664.x
Subject(s) - polyclonal antibodies , monoclonal antibody , antigen , microbiology and biotechnology , antibody , immunization , monoclonal , virology , biology , chemistry , immunology
The production of a monoclonal antibody which detects the low‐incidence red cell antigen Wr a is described. The antibody (BGU1‐WR) was isolated following immunization of BALB/tk mice with Wr(a+) cells. BGU1‐WR is an IgGl antibody and reacted in a manner similar to human polyclonal anti‐Wr a with untreated, protease treated and chemically modified Wr(a+) cells.