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Serotype Switching in a Partially Deleted RHD Gene
Author(s) -
Blunt Tracy,
Daniels Geoff,
Carritt Ben
Publication year - 1994
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1994.tb01280.x
Subject(s) - haplotype , gene , biology , genetics , serotype , antigen , genome , rh blood group system , recombinant dna , virology , antibody , allele
We have studied the RH genes in donors with the RhD‐negative haplotype dCe s . In contrast to the usual arrangement of genes in RhD‐negative individuals, where the lack of antigen expression is due to deletion of the entire RHD gene, we find that the dCe s haplotype includes an RHD gene with an internal deletion. Moreover, there appear to be no 5′ sequences characteristic of RHC suggesting that the RhC antigen may be encoded by a truncated RHD or a recombinant RHD/CE gene in these dCe s /dce genomes.