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Use of ‘Split’ Plateletpheresis Products for Alloimmunized Patients
Author(s) -
Gharpure Vishwanath S.,
Norris Dottie,
Lee Edward J.,
Schiffer Charles A.
Publication year - 1994
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1994.tb01250.x
Subject(s) - plateletpheresis , apheresis , medicine , platelet , platelet transfusion , surgery , blood transfusion
Single donor platelets obtained using the COBE Spectra were split into two halves and administered to alloimmunized patients with leukemia at two different points in time. The mean platelet yield was 6.83 times 10 11 (n = 63) with 56% of collections having yields of >6.0times10 11 (i.e. twice the current AABB recommendation for an apheresis platelet transfusion). In 58 instances, the two halves were administered to the same patient 24–96 h apart. The differences in the correct increments of the split transfusions administered 24–48 h apart were not statistically significant, although there were decreased increments after 72 and 96 h of storage. In 5 instances when the CCI for first transfusion was unacceptably low, the second half was successfully transfused to another patient. This study proves it is feasible to split apheresis platelets into two transfusions, and discusses approaches to optimally use this strategy for the transfusion support of alloimmunized patients.