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In vitro Evaluation of a New Filter for Leucocyte Depletion of Platelet Concentrate during Component Preparation
Author(s) -
Christensen Lisa Dalh,
Dickmeiss Ebbe
Publication year - 1994
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1994.tb01249.x
Subject(s) - in vitro , platelet , component (thermodynamics) , chemistry , immunology , medicine , biochemistry , physics , thermodynamics
A newly developed filter for prestorage leucocyte depletion of platelet concentrates (PC) was studied. The filter is designed for leucocyte depletion during the preparation of the pool PC from platelet rich buffy coats. In all the leucocyte depleted PC (LD‐PC) leucocyte depletion was satisfactory. 19 of 20 units of LD‐PC had a leucocyte content below 3times10 5 per PC and 1 contained 8times10 5 leucocytes. The standard PC contained 2.53times10 8 (0.87times10 8 –15.3times10 8 ; n = 20) leucocytes per PC (median and range). The quality of the LD‐PC was evaluated by measuring platelet activation, platelet morphology, and pre‐ and poststorage pH. There were no differences in any of the parameters studied.