Premium
Investigation of an Outbreak of Hepatitis A in Irish Haemophilia A Patients
Author(s) -
Lawlor E.,
Johnson Z.,
Thornton L.,
Temperley I.
Publication year - 1994
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1994.tb00968.x
Subject(s) - irish , haemophilia a , medicine , haemophilia , outbreak , transmission (telecommunications) , hepatitis , serology , blood product , hepatitis a , virology , hepatitis b , viral hepatitis , pediatrics , immunology , surgery , antibody , philosophy , linguistics , electrical engineering , engineering
Since 1990, Irish haemophilia A patients have been treated with solvent‐detergent(SD)‐treated virally inactivated high‐purity factor VIII concentrate prepared from plasma from Irish voluntary non‐remunerated donors. In 1992, 13 haemophilia A patients developed clinical hepatitis A and a further 17 patients showed serological evidence of recent infection by hepatitis A. All but 3 of these patients had had recent exposure to SD‐treated product. A case‐control study is underway to determine whether these cases represent transmission through product or environmentally acquired hepatitis A.