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Serological Characteristics of Partial D Antigen Category VI in 8 Unrelated Blood Donors
Author(s) -
Rhenen D.J.,
Thijssen P.M.H.J.,
Overbeeke M.A.M.
Publication year - 1994
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1994.tb00295.x
Subject(s) - serology , medicine , immunology , antigen , isoantibodies , antibody
Classification of subjects with a partial D antigen is traditionally performed with immune anti‐D sera. The development of monoclonal antibodies enables a fine analysis to be made of the specificity of the epitopes that are present or missing in these cases. A systematic search in a Caucasian donor population of 17,500 revealed 8 unrelated male individuals (frequency 0.05%) with a red cell phenotype characteristic of partial D category VI, but without anti‐D in their serum. The relation to the ‘classic’ partial D category VI was investigated and is discussed, as is the observed serological heterogeneity of the partial D category VI group. Clinical consequences for the prevention of immunization of these subjects are mentioned.