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Alloimmunisation via Previous Transfusion Places Female Kp b ‐Negative Recipients at Risk for Having Children with Clinically Significant Hemolytic Disease of the Newborn
Author(s) -
Gorlin Jed B.,
Kelly Lydia
Publication year - 1994
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1994.tb00275.x
Subject(s) - medicine , disease , hemolytic disease of the newborn (abo) , isoantibodies , immunology , antibody , pediatrics , pregnancy , fetus , biology , genetics
We report a case of clinically significant hemolytic disease of the newborn due to Kp b alloimmunisation requiring obstetric intervention. This case and a review of the literature are in contrast to reviews of hemolytic disease of the newborn that either ascribe no significance to the Kp b antigen or suggest that it causes only rare or mild disease. Analysis of our Kp b ‐negative donor pool suggests that prior transfusion greatly increases the chance of alloimmunisation. The role of frozen rare donor registry cells as a public resource is emphasised.