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Protection Against Rh D‐Haemolytic Disease of the Newborn by a Diminished Transport of Maternal IgG to the Fetus
Author(s) -
Dooren Marion C.,
Engelfriet C. Paul
Publication year - 1993
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1993.tb04526.x
Subject(s) - haemolytic disease , fetus , medicine , hemolytic disease of the newborn (abo) , antibody , disease , pregnancy , immunology , fetal circulation , rh blood group system , placenta , biology , genetics
IgG present in the circulation of newborn infants is predominantly of maternal origin. In cases of severe Rh D alloimmunization, the maternal anti‐D antibodies may lead to Rh D‐haemolytic disease of the newborn. However, an impaired placental transport of maternal IgG could be associated with the protection of the fetus/newborn against haemolytic disease as shown in this case report.