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Anti‐Gammaglobulin Factors in Human Sera Revealed by Enzymatic Splitting of Anti‐Rh Antibodies
Author(s) -
Osterland C. K.,
Harboe M.,
Kunkel H. G.
Publication year - 1993
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1993.tb03065.x
Subject(s) - agglutination (biology) , antibody , titer , pepsin , gamma globulin , proteolysis , enzyme , rheumatoid factor , immunology , immunoglobulin g , rheumatoid arthritis , chemistry , medicine , biochemistry
Abstract Human sera were found that contained antibody activity which caused agglutination of red cells or particles sensitized with immunoglobulin G that had first been degraded by pepsin proteolysis. The agglutinating activity was specific for a determinant that was not present on the untreated, native immunoglobulin. It was found most frequently in sera from rheumatoid arthritis patients and its titre showed some correlation with disease activity.