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Possible Genetical Pathways for the Biosynthesis of Blood Group Mucopolysaccharides
Author(s) -
Watkins W. M.,
Morgan W. T. J.
Publication year - 1993
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1993.tb03064.x
Subject(s) - abo blood group system , gene , blood group antigens , biosynthesis , antigen , enzyme , genetics , biology , biochemistry , computational biology , immunology
This paper put forward possible biosynthetic pathways for the formation of the blood group A, B, H and Lewis antigens based on the limited knowledge of their chemistry and genetics that was available in 1959. The schemes proposed that genes at four independent loci ABO, HH, Lele and Sex interacted to give the five specificities A, B, H, Le a and Le h found in secretions and that the primary products of the blood group genes were not the antigens but enzymes that catalysed the sequential addition of single sugars to complete the determinants.