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Posttransfusional Hemolysis in Recipients of Glucose‐6‐Phoiphate Dehydrogenase‐Deficient Erythrocytes
Author(s) -
Shalev Oded,
Manny Noga,
Sharon Raphael
Publication year - 1993
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1993.tb02525.x
Subject(s) - hemolysis , lactate dehydrogenase , glucose 6 phosphate dehydrogenase deficiency , medicine , glucose 6 phosphate dehydrogenase , bilirubin , glucosephosphate dehydrogenase deficiency , red blood cell , hemolytic anemia , immunology , dehydrogenase , gastroenterology , enzyme , biology , biochemistry
To test the hypothesis that transfusion of blood donated by individuals with glucose‐6‐phosphate dehydrogenease (G6PD) deficiency may result in a hemolytic reaction, we conducted a prospective longitudinal study in which 10 patients transfused with 1 unit of G6PD‐deficient and 1 unit of normal red blood cells (RBC) were compared with 10 patients transfused with 2 units of age‐matched normal RBC. We found that 24 h after transfusion serum bilirubin (μmol/1) in the recipients of G6PD‐deficient RBC was significantly higher than in the recipients of normal RBC (36±14 vs. 18±5, respectively, p>0.004). A parallel increase was found in the serum lactate dehydrogenase (LDH; IU/1) between the two groups (378±151 vs. 264±56, p<0.001). The difference in serum bilirubin(26±10 vs. 15±5, p<0.03) was still noted 48 h after transfusion, with only a marginal difference (p<0.08) in LDH. We conclude that an immediate posttransfusional hemolytic reaction can occur in recipients of G6PD‐deficient RBC and therefore suggest that the differential diagnosis of posttransfusional hemolysis, particularly in populations where G6PD deficiency is prevalent, includes transfusion of erythrocytes from G6PD‐deficient donors.