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Intravenous Immunoglobulin Therapy of Autoimmune and Systemic Inflammatory Diseases
Author(s) -
Ronda Nicoletta,
Hurez Vincent,
Kazatchkine Michel D.
Publication year - 1993
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1993.tb02521.x
Subject(s) - medicine , intravenous immunoglobulin therapy , intravenous immunoglobulins , immunology , antibody , intensive care medicine
The proven beneficial effect of intravenous immunoglobulins (IVIg) in certain autoimmune disorders has led to the development of clinical trials in other autoimmune and systemic inflammatory diseases. In parallel, experimental studies are being carried out to better understand the mechanisms of action of IVIg. In this review, we discuss the clinical use of IVIg in autoimmune disorders and the possible mechanisms by which IVIg may be effective in the various diseases. A better understanding of the mechanisms of action of IVIg in autoimmune disease will allow optimization of their use as a therapeutic alternative to conventional immunosuppression.