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Effectiveness of Four Intravenous IgG Preparations in Prevention of Phagocytosis of Anti‐Rh‐(D)‐Coated Erythrocytes by Mononuclear Phagocytes
Author(s) -
Sheth Kirtikant V.,
AlSedairy Sultan,
Lee Jennifer
Publication year - 1993
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1993.tb02145.x
Subject(s) - phagocytosis , antibody , incubation , peripheral blood mononuclear cell , chemistry , immunoglobulin g , fc receptor , immunology , microbiology and biotechnology , biology , in vitro , biochemistry
Four commercial intravenous immunoglobulin G (IGIV) preparations, Sandoglobulin (Sandoz), Intraglobin (Biotest), Gammonativ (Kabivitrum) and Gammaogard (Kabivitrum) showed percent inhibition of Fc receptor‐mediated phagocytosis of anti‐Rh(D)‐coated erythrocytes as follows: 45±14 SD, 41±23 SD, 35±14 SD, 25±13 SD, respectively. Pre‐incubation of Rh(D)‐positive and antibody‐coated Rh(D)‐positive erythrocytes with IGIV did not lead to any inhibitory effects on phagocytosis. However, preincubation of mononuclear phagocytes with IGIV gave marked inhibition of phagocytosis of antibody‐coated erythrocytes. In summary, all four IGIV preparations showed Fc receptor‐mediated inhibition of phagocytosis of anti‐Rh(D)‐coated erythrocytes by mononuclear phagocytes.