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Distribution of Polymorphic HLA‐DR and ‐DQ Alleles as Determined by Restriction Fragment Length Polymorphism Analysis in an Austrian Population
Author(s) -
Fischer Gottfried F.,
Faé Ingrid,
Pickl Winfried F.
Publication year - 1992
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1992.tb01205.x
Subject(s) - restriction fragment length polymorphism , genetics , restriction enzyme , biology , hla dq , haplotype , allele , allele frequency , polymorphism (computer science) , population , restriction fragment , human leukocyte antigen , exon , restriction site , genetic linkage , microbiology and biotechnology , gene , genotype , antigen , medicine , environmental health
The restriction fragment length polymorphism (RFLP) of HLA‐DR β, ‐DQ α and ‐DQ β genes was analyzed in 637 unrelated individuals from the Austrian population. The restriction enzyme was Taq I, and three exon‐specific probes were applied. The gene frequencies, the Hardy‐Weinberg equilibrium in DR β and DQ loci, linkage disequilibria between the loci and haplotype frequencies are calculated. Rare associations between DR and DQ loci are described. Two RFLP patterns are demonstrated which were unique in the overall 1,000 individuals tested so far.