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Autoantibodies in HIV‐infected Hemophilia Patients against Different Epitopes on CD4+Lymphocytes and Recombinant CD4
Author(s) -
Daniel V.,
Weimer R.,
Zettlmeissl G.,
Langner K.,
Zimmermann R.,
Opelz G.
Publication year - 1992
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1992.tb01165.x
Subject(s) - asymptomatic , autoantibody , antibody , immunology , medicine , recombinant dna , immunopathology , cd8 , virology , human immunodeficiency virus (hiv) , viral disease , t lymphocyte , epitope , aids related complex , immune system , biology , biochemistry , gene
We studied 684 sera obtained from 20 hemophilia patients with AIDS/AIDS‐related complex (ARC), 89 asymptomatic HIV+, 76 HIV‐ hemophilia patients and 151 healthy controls for antibodies against recombinant CD4 (rCD4). Twenty‐two percent of AIDS/ARC patients, 10% of asymptomatic HIV+ patients, 17% of HIV‐ patients, and 1% of healthy controls had anti‐rCD4 antibodies. Purified anti‐rCD4 antibodies did not react with human CD4+lymphocytes. This may explain why formation of anti‐rCD4 antibodies correlated neither with the occurrence of autoantibodies against CD4+lymphocytes nor with a decrease in CD4+cell counts. Antibodies that were eluted from CD4+lymphocytes after sequential adsorption and elution with separated CD8+and CD4+cells reacted with CD4+lymphocytes of only some healthy individuals, suggesting diversity of CD4 expression.